Neuromodulation: The Biochemical Control of Neuronal Excitability by Leonard K. KaczmarekNeuromodulation: The Biochemical Control of Neuronal Excitability by Leonard K. Kaczmarek

Neuromodulation: The Biochemical Control of Neuronal Excitability

EditorLeonard K. Kaczmarek, Irwin B. Levitan

Hardcover | February 1, 1992

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This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellularcalcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simplersystems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.
Leonard K. Kaczmarek is at Yale University. Irwin B. Levitan is at Brandeis University.
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Title:Neuromodulation: The Biochemical Control of Neuronal ExcitabilityFormat:HardcoverDimensions:304 pages, 9.57 × 6.38 × 1.02 inPublished:February 1, 1992Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:019504097X

ISBN - 13:9780195040975

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Table of Contents

1. Leonard K. Kaczmarek and Irwin B. Levitan: What is Neuromodulation?2. Irwing B. Levitan and Leonard K. Kaczmarek: Ion Currents and Ion Channels, Substrates for Neuromodulation3. Christopher Miller: Mechanisms and Modulation of Ion Channel Proteins4. Richard L. Huganir: Biochemical Mechanisms in the Modulation of Ion Channel Function5. Richard L. Huganir: Phosphorylation of Purified Ion Channel Proteins6. Jack A. Benson and William B. Adams: Modulation of the Endogenous Rhythmic Bursting Activity in the Aplysia Neuron R157. Judith A. Strong and Leonard K. Kaczmarek: Modulation of Voltage-Dependent Potassium Currents During Long-Lasting Changes in Neuronal Activity8. Douglas A. Ewald and Leonard K. Kaczmarek: Modulation of Ion Channels Which are Regulated by Calcium9. Stephen W. Jones and Paul R. Adams: Modulation of Potassium Currents of Vertebrate Neurons10. Stephen A. Siegelbaum: Modulation of a Potassium Channel in Aplysia Ssensory Neurons by Cyclic AMP-dependent Protein Phosphorylation11. Richard W. Tsien: Modulation of Calcium Currents in Heart Cells and Neurons12. Robert S. Zucker: Neurotransmitter Release and Its Modulation13. Val Gribkoff and F. Edward Dudek: Neuromodulation in the Mammalian Brain: The New Frontier

Editorial Reviews

"The first chapter of [this book] is devoted to a definition and description of what is meant by the term neuromodulation: "The ability of neurons to alter their electrical properties in response to intracellular changes resulting from synaptic or hormonal stimulation." In the opinion of thereviewer this is a very good restriction, as it appears that this field of cellular neurobiology shows exciting developments....A very good book for general neurobiologists to get quickly acquainted with the newly emerging insights into the mechanisms which neurons use, to change their excitabilitylevel. In addition it provides the specialist with an opportunity to broaden his outlook in the field of neurobiology."--Journal of the Neurological Sciences