Seizures and Epilepsy

Hardcover | January 2, 2013

byJerome Engel

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This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epilepticphenomena, as well as current diagnosis and treatment, have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. According to the World Health Organization, epilepsy accounts for 1% of the global burden of disease, equivalent to breast cancer in women and lung cancer in men. Among primary disorders of the brain, it is equivalent to depression, dementia, and substance abuse. Singly authored by Jerome Engel, Jr,this must-read from 1989 reasserts itself as a modern classic comprehensive textbook covering a broad range of both basic and clinical epileptology. Basic scientists who are interested in learning more about clinical epileptology, as well as clinicians who would like to understand more aboutfundamental mechanisms will find this text useful. Residents and postdoctoral fellows, particularly those interested in a career in epilepsy, will benefit from the continuity and organization of this single-authored comprehensive textbook.

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This second edition of Seizures and Epilepsy, written almost a quarter of a century after the ground-breaking first edition, is more than an update: it is a complete revision due to tremendous advances in the field. Our understanding of the fundamental neuronal mechanisms underlying epilepticphenomena, as well as current diagnosis and ...

Jerome Engel, Jr., MD, PhD, is Director of the Seizure Disorder Center, and The Jonathan Sinay Distinguished Professor of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences at UCLA. He is past president of the American Clinical Neurophysiology Society, the American Epilepsy Society, and the International League against...

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Format:HardcoverDimensions:736 pages, 10 × 7 × 0.98 inPublished:January 2, 2013Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:019532854X

ISBN - 13:9780195328547

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Table of Contents

Part I: Introduction1. Terminology and ClassificationsTerminologyClassificationsSummary and Conclusions2. PerspectivesEpilepsy Then - Historical PerspectiveEpilepsy Now - Epidemiological PerspectiveSummary and ConclusionsPart II: Pathophysiology3. Mechanisms of Neuronal Excitation and SynchronizationThe NeuronNeuronal NetworksPhylogeny and OntogenySystemic InfluencesNeuronal Basis of EEG ActivityMethodological DevelopmentsSummary and Conclusions4. Basic Mechanisms of Seizures and EpilepsyExperimental Models of Seizures and EpilepsyStudies of Human EpilepsyMolecular Genetic InvestigationsPossible Mechanisms of Human Epileptic PhenomenaSummary and Conclusions5. Causes of Human EpilepsyNonspecific Predisposing FactorsSpecific Epileptogenic DisturbancesPrecipitating FactorsSummary and ConclusionsPart III: Phenomenology6. Epileptic SeizuresNeurobiological Considerations for the Diagnosis of Epileptic Seizure TypesTypes of Epileptic SeizuresFocal SeizuresEEGGeneralized SeizuresEEGUnclassified SeizuresMyoclonusSummary and Conclusions7. Epilepsy SyndromesNeonatal PeriodInfancyChildhoodAdolescence-AdultLess Specific Age RelationshipDistinctive ConstellationsConditions With Epileptic Seizures That Are Traditionally Not Diagnosed as a Form of Epilepsy Per SeMyoclonic SyndromesSummary and Conclusions8. EpileptogenesisThe Development of EpilepsyThe Progressive Nature of EpilepsyEpileptic Seizures and Brain DevelopmentSummary and Conclusions9. Periictal PhenomenaIctal InitiationSleep-Wake Cycles and ChronobiologyMetabolic and Toxic InfluencesPsychological StressPostictal SymptomsMortalitySummary and Conclusions10. Status EpilepticusGeneralized Convulsive Status EpilepticusAbsence Status EpilepticusEpilepsia Partialis ContinuaFocal Dyscognitive (Complex Partial) Status EpilepticusSubtle Status EpilepticusFebrile Status EpilepticusNeonatal Status EpilepticusEpileptic Brain DamageSummary and Conclusions11. Chronic Behavioral DisturbancesEpidemiology of Psychiatric Comorbidity in EpilepsyPhenomenology of Behavioral Disturbances in EpilepsyMechanisms of Interictal Behavioral Disturbances in EpilepsySummary and ConclusionsPart IV: Management12. Diagnostic EvaluationHistoryAntiseizure Drug HistoryPhysical ExaminationLaboratory ExaminationPsychological EvaluationBiomarkersSummary and Conclusions13. Differential DiagnosisDifferential Diagnosis of Nonepileptic Paroxysmal EventsDifferential Diagnosis of Reactive (Acute Symptomatic, Provoked) Epileptic SeizuresDifferential Diagnosis of Chronic EpilepsyThe Use of the EEG in the Differential Diagnosis of EpilepsyThe Use of Functional Imaging in the Differential Diagnosis of EpilepsySummary and Conclusions14. General Principles of TreatmentPharmacological TreatmentMedically Refractory SeizuresAlternative TherapyPsychosocial ConsiderationsThe Use of EEG in Assessing TreatmentManagement After a Single SeizureEmergency TreatmentSummary and Conclusions15. Antiseizure DrugsStandard Older DrugsNewer DrugsSpecial and Rarely Used DrugsNew Drug DevelopmentDrugs Under InvestigationSummary and Conclusions15. Antiseizure DrugsStandard Older DrugsNewer DrugsSpecial and Rarely Used DrugsNew Drug DevelopmentDrugs Under InvestigationSummary and Conclusions16. Nonpharmacological Therapy of SeizuresSurgical TherapyVagus Nerve Stimulation (VNS)Hormone TherapyImmune TherapyComplementary and Alternative Medicine (CAM)Summary and Conclusions17. Social ManagementStigmaQuality of LifeActivities of Daily LivingFamilySchoolEmploymentLegal RightsInsuranceFinancial AidResourcesHealth Care DisparitiesSummary and Conclusions